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Traumatic Brain Injury and Risk of Dementia and Alzheimer's DiseaseA Comprehensive Guide to the Literature for Personal Injury Lawyers
Publisher: Medifocus Legal
Publication Date: February 8, 2024
Number of Pages: 137
A Comprehensive Guide to the Literature for Personal Injury Lawyers
Publisher: Medifocus LegalPublication Date: February 8, 2024
Number of Pages: 137
Traumatic brain injury occurs when an external force injures the brain, leading to a disruption in normal brain function. The severity of TBI can range from mild concussions to severe, life-threatening injuries. Studies have shown that individuals who sustain a TBI may be at an increased risk of developing dementia, including Alzheimer's disease, later in life. The exact mechanisms underlying this association are complex and multifactorial but may involve neuroinflammation, protein aggregation in the brain, and neurodegeneration.
Alzheimer's disease, the most common form of dementia, is characterized by progressive cognitive decline and memory impairment. While not all individuals with a history of TBI will develop dementia, several studies have demonstrated a higher prevalence of dementia among TBI survivors compared to the general population. Furthermore, the risk of dementia appears to be dose-dependent, with more severe TBIs being associated with a higher risk.
In the legal arena, proving causation between TBI and subsequent dementia can be challenging. Legal professionals must navigate complex medical evidence combined with persuasive legal arguments in an attempt to prove a causative link between the injury and subsequent cognitive and memory impairment. Understanding this association, however, is crucial for both legal professionals and their medical experts in cases where an individual developed dementia and is now seeking compensation from negligence or an accident that resulted in a TBI.
These cases often require expert testimony from neurologists, neuropsychiatrists, and other medical specialists. Arming these experts with authoritative literature can significantly bolster their opinions and credibility in providing evidence-based testimony based on sound science to offer insight into the association between TBI and dementia.
The MediFocus Literature Guide to Traumatic Brain Injury and Risk of Dementia and Alzheimer's Disease is a comprehensive reference guide to the literature designed to provide personal injury lawyers and their medical experts with a detailed overview of the available scientific evidence regarding the association between TBI and subsequent development of dementia. This is accomplished through a comprehensive overview of the peer-reviewed literature published over the past two decades as documented from individual case reports, cohort studies, meta-analysis, and major topical review articles.
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- A comprehensive bibliography of 151 journal article references indexed in MEDLINE published in well respected medical and scientific journals.
- Online access to the abstracts (summaries) of the articles.
- Online access to the free full-text version of 74 articles.
- Links to full-text sources of other articles that are available for purchase directly from individual journal publishers.
- A unique "Author Directory" consisting of the names and institutional affiliations of experts who have published and have specialized knowledge about Traumatic Brain Injury and Risk of Dementia and Alzheimer's Disease. The "Author Directory" is a valuable resource for quickly identifying and locating experts for case reviews, opinions, and testimony.
Select examples of topics that are covered by the articles referenced in this Guidebook include:
- Differences in Risk of Alzheimer's Disease Following Later-Life Traumatic Brain Injury in Veteran and Civilian Populations.
- How Traumatic Brain Injury History Relates to Brain Health MRI Markers and Dementia Risk
- Traumatic Brain Injury Associates with an Earlier Onset in Sporadic Frontotemporal Dementia
- Systematic Review, Meta-Analysis, and Population Attributable Risk of Dementia Associated with Traumatic Brain Injury in Civilians and Veterans.
- Blunt Traumatic Brain Injury and Alzheimer Pathology.
- Traumatic brain injury fast-forwards Alzheimer's pathology: evidence from amyloid positron emission tomorgraphy imaging.
- Head injury and 25-year risk of dementia.
- Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia.
- Traumatic Brain Injury and Risk of Alzheimer's Disease and Related Dementias in the Population.
- Mild TBI in the elderly - risk factor for rapid cognitive impairment in Alzheimer's disease
- Association of traumatic brain injury with dementia and memory decline in older adults in the United States.
- Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review.
- Mild Traumatic Brain Injuries and Future Risk of Developing Alzheimer's Disease: Systematic Review and Meta-Analysis.
- Traumatic Brain Injury as a Risk Factor for Dementia and Alzheimer Disease: Critical Review of Study Methodologies.
- Traumatic brain injuries among veterans and the risk of incident dementia: A systematic review & meta-analysis.
- Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer's disease.
- Association of traumatic brain injury with dementia and memory decline in older adults in the United States.
- Traumatic Brain Injury and Age of Onset of Dementia with Lewy Bodies.
- Brain Injury-Mediated Neuroinflammatory Response and Alzheimer's Disease.
- Traumatic Brain Injury and Risk of Long-Term Brain Changes, Accumulation of Pathological Markers, and Developing Dementia
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